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Moreover, fetuses from dams supplemented with RPM were able to maintain methionine homeostasis by shunting methionine through adjacent pathways (transsulfuration), contradicting the hypothesis that GAA supplementation would induce a methionine deficiency and compromise fetal methyl balance (Crouse et al., 2023)

For this reason, many compounding pharmacies recommend using a new vial within 14 days of first opening it, even if the original 28-day refrigerated timeline hasn't elapsed